Antibody-Mediated Rejection of Solid-Organ Allografts

Categories: Noticias

This review focuses on current standards for management of antibody-mediated rejection in solid-organ transplant recipients and emphasizes advances that may ultimately lead to the development of precise, pathogenesis-based therapeutic approaches.

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

We thank Drs. Duong Van Huyen, Michael Mengel, Patrick Bruneval, Dylan Miller, Antoine Roux, Leila Zemoura, Elisabeth Longchampt, Stijn Verleden, and Jan von der Thüsen for providing the histologic images, and Dr. Luis Hidalgo for help in building the figure on prototypical immune responses.

Author Affiliations

From the Paris Translational Research Center for Organ Transplantation, INSERM, Unité Mixte de Recherche S970 (A.L., C.L.), the Kidney Transplant Department, Necker Hospital, Assistance Publique–Hôpitaux de Paris (AP-HP) (A.L.), and the Kidney Transplant Department, Saint-Louis Hospital, AP-HP (C.L.) — all in Paris.

Address reprint requests to Dr. Loupy at the Paris Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S970, 56 Rue Leblanc, 75015 Paris, France, or at .

FUENTE: www.nejm.org

Author: Satot

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